Here are our results as audited by American Accounting, Sarasota, Florida:
All ages of patients treated are combined. Patient age range = 27- 49 years (2016), 22-49 years (2017)
2016: All Pre-implantation Genetic Screening (PGS) Embryo Transfers
All PGS Frozen/Thawed Embryo Transfers, Pregnancy rate = 81%, Live births= 62%
2016: Single PGS Thawed Embryo Transfers (only 1 embryo implanted): Pregnancy rate = 80%, Live Birth = 59%
In 2016, There were 4 thawed PGS embryo transfers when 2 embryos were transferred. All resulted in pregnancies. Three were singleton births and one a twin birth.
2017: All Pre-implantation Genetic Screening (PGS) Embryo Transfers (Jan-July)
All PGS Frozen/Thawed Embryo Transfers Pregnancy rate = 83%, Ongoing pregnancies = 60%
2017: Single PGS Thawed Embryo Transfers (only 1 embryo implanted): Pregnancy rate = 82%, Ongoing pregnancies = 59%
In 2017, there has been 1 treatment when 2 thawed embryos were transferred after PGS and this has resulted in our only twin pregnancy so far this year.
The word “Euploid” is a genetic term that describes the presence of a normal number of chromosomes. Single Euploid Embryo Transfer IVF Statistics are what really matter. IVF treatments are changing as are IVF statistics. We are among the progressive IVF clinics around the world that have embraced new technologies that have improved embryo selection processes.
It is well known that the most common complication of Assisted reproductive techniques are the complicated multiple pregnancies (twins, triplet, and higher number pregnancies) that result when more than one embryo is implanted (or transferred). For example, twin pregnancies have as much as a 4-6 times higher risk of congenital anomalies, 4-6 times higher risk of cerebral palsy, as well as many other pregnancy complications including a 4 times higher risk of fetal death and need for a cesarean section. With that in mind, top doctors and scientists have tried to develop new IVF technology for selecting single embryos for transfer for all patients regardless of the mother’s age.
Past protocols were simply based on the appearance of the embryos. It had been standard practice to implant or transfer 1 or 2 embryos if the patient’s age was less than 32, 2 embryos if the egg age was 32-36, 2-3 embryos would be implanted if the patient was 36-39 years old and so on. Patients in their 40’s would routinely receive 4-5 embryos. This was the case because the older the egg, the higher the chance of a genetic abnormality that would prevent development past the earliest stages. For the past 20 years, the average twin pregnancy rate per IVF in the younger patients was 25-30%. That was such a large number that if one saw a twin pregnancy or twins, there was 65% chance that the pregnancy was the result of some type of Assisted reproductive technique.
Our goal has been to apply technologies that would give us so much information about the embryo that we could shift our IVF program to a single embryo transfer program regardless of the maternal age. That is, for example, a 23 year old, a 35 year old, a 43 year old would all have the same plan for a single embryo transfer and therefore avoid the risks associated with a multiple pregnancy.
We have been leaders in Florida in the application of pre-implantation genetic screening (PGS) and pre-implantation genetic diagnosis (PGD) as evidenced by our first pregnancy in 1999 and the subsequent delivery of that healthy baby girl in 2000. From 1999 until the present, the instruments, techniques, and processing of the cells from the embryos have evolved so that we gather more information and have much more reliable results. From 1999 until the end of 2012, we based our decisions on one or two cells taken from a 3 day old embryo. Since 2013, we have shifted to testing the 5 or 6 day old embryo. This allows us to test a smaller portion of the embryo and at the same time test a larger number of cells (8-10) that are more advanced. These cells are from the trophectoderm or future placenta.
In 2017, we instituted pre-release audits of our results by and independent accounting firm. American Accounting of Sarasota has audited our Pre-implantation Genetic Screening program for 2016 and the first half of 2017. We chose to do this because we are ahead of the trend in reporting what really matters: cumulative age IVF results per single euploid (23 pairs of chromosomes detected) embryo transfers.